Furthermore, it has been demonstrated that the expression of LOX-1 and oxidative stress are key events in the atherosclerotic process, as they lead to the activation of the transcription factor NF-κB, the ERK1/2 and p38 MAP kinases, and the enzyme NOX, events linked to endothelial dysfunction [27,31]. This evidence concerns the gene NFKB1 and endothelial dysfunction.