These genes include GRIA3, TAF7L, ARL14, PCDHGA9, MDGA1, ZFPM2, OSR2, TMC8/TMC6, HCN2, and CDK5R2, which are likely to be relevant in human lung cancer and are also epigenetically deregulated upon exposure to ECS in our animal study. The gene discussed is OSR2; the disease is lung cancer.