-inhibited the mRNA expression of miR-21, CTGF, α-SMA, TIMP-1, and TGF-β1 and the protein expression of p-Smad2, p-Smad3, p-Smad2/3, CTGF, α-SMA, TIMP-1, and TGF-β1 both in vitro and in vivo-↑ the mRNA and protein expression of Smad7 and MMP-9-↓ the degree of liver fibrosis-↓ α-SMA and Col-1 expression in liver tissue-↓ TGF-β1 in serum. The gene discussed is SMAD3; the disease is Hepatic fibrosis.