-↓ liver fibrosis by inhibiting liver function, liver fibrosis index, and collagen deposition in vivo-↓ ALT, AST, HA, CIV, LN, PIIIP-↓ HYP-↓ α-SMA, TGF-β1, PDGF-βR, CTGF, desmin, and vimentin-inhibited the PI3K/AKT/mTOR signaling cascade-↓ p-AKT, p-mTOR, p-p70S6K1-prevented the stimulation of hepatic stellate cells and the synthesis of ECM-↓ the hepatocyte apoptosis-↑ Bcl-2-↓ Bax-↓ caspase-3 and cleaved caspase-3. This evidence concerns the gene DES and Hepatic fibrosis.