These bioactive compounds operate through various pathways, including the TGF-β/Smad signaling pathways, AMPK/mTOR, Wnt/β-catenin, NF-κB, PI3K/AKT/mTOR, hedgehog pathways, and other factors associated with hepatic fibrosis. This evidence concerns the gene TGFB1 and Hepatic fibrosis.