-regulated cell viability in TNF-α-induced HSC-T6 cells via regulation on TGF-β signaling pathway-↓ TGF-β, p-Smad2, p-ERK, and c-Jun-attenuated the alteration of phenotype associated with TAA-induced liver damage and fibrosis in mice-↓ collagen-attenuated TAA-induced liver damage and fibrosis in mice-played a protective role in liver fibrosis through regulation of the TGF-β signaling pathway-↓ the protein expression of p-Smad2, p-ERK, and c-Jun-inhibited the mRNA level of IL-6 and TNF-α in TAA-induced mice. This evidence concerns the gene SMAD2 and Hepatic fibrosis.