Additionally, some flavones enhance antioxidant defenses and modulate pathways such as Nrf2 (alpinetin), cGAS-STING (oroxylin A), and Hippo/YAP and autophagy pathways (nobiletin), repressing the miR-17-5p/Wnt/β-catenin signaling (diosmin), suppressing TGF-β1-induced Smad and AKT signaling (luteolin), inhibiting the TLR2/TLR4 pathway (luteoloside), blocking the p38 MAPK and PDGF-Rβ signaling pathways (tricin), and contributing to the attenuation of liver fibrosis and the restoration of normal liver structure and function in various cell and animal models. The gene discussed is TLR4; the disease is Hepatic fibrosis.