AKT1 and Hepatic fibrosis: Additionally, some flavones enhance antioxidant defenses and modulate pathways such as Nrf2 (alpinetin), cGAS-STING (oroxylin A), and Hippo/YAP and autophagy pathways (nobiletin), repressing the miR-17-5p/Wnt/β-catenin signaling (diosmin), suppressing TGF-β1-induced Smad and AKT signaling (luteolin), inhibiting the TLR2/TLR4 pathway (luteoloside), blocking the p38 MAPK and PDGF-Rβ signaling pathways (tricin), and contributing to the attenuation of liver fibrosis and the restoration of normal liver structure and function in various cell and animal models.