-ameliorated histopathological characteristics and hepatic fibrosis markers in mice-↓ α-SMA, Col-1, TGF-β1-inhibited activation of MAPK and P-Smad2/3L and P-Smad2C-↑ phosphorylation of P-Smad3C-modulated MAPK pathway activation and Smad2/3 phosphorylation in TGF-β1-stimulated HSCs-↓ P-ERK1/2, P-JNK1/2, P-p38, P-Smad2C, P-Smad2L, P-Smad3C, and P-Smad3L-↑ P-Smad3C-inhibited the expression of PAI in TGF-β1-stimulated HSCs. This evidence concerns the gene MAPK8 and Hepatic fibrosis.