-improved systemic insulin sensitivity without altering adiposity-↓ ALT, AST-attenuated hepatic signaling pathways associated with NLRP3 inflammasome activation: TLR4/NF-κB, and endoplasmic reticulum/oxidative stress-↓ circulating IL-1β levels-ameliorated hepatic fibrosis-↓ the excessive deposition of collagen fibers-↓ α-SMA-normalized the expression of TGF-β, Col1α2, Col3α1, Col4α1, and TIMP-1-↓ NLRP3 activation and caspase-1 cleavage. The gene discussed is CASP1; the disease is Hepatic fibrosis.