In a triple-transgenic AD mice model, a high dose of folic acid (3 mg/dL folate in drinking water, combined with intragastric administration of 1.2 mg/kg folate every day) provided cardioprotection, as it increased SIRT1-related protein (AMPK, SIRT1, SOD-2) and survival signaling protein (IGF1 receptor, pPI3K, pAKT, pBad) levels and reduced apoptotic cardiac cells. The gene discussed is SIRT1; the disease is Alzheimer disease.