Kashubians are characterized by an exceptionally high frequency of pathogenic HADHA c.1528G>C (p.Glu510Gln) allele (carrier frequency up to 1:57), which is associated with severe recessive encephalocardiomyopathy and HELLP syndrome in heterozygous carriers pregnant with a fetus with biallelic HADHA inactivation [68]. Here, HADHA is linked to HELLP syndrome.