ACTA1 and autoimmune hepatitis: AIH is a T cell-mediated inflammatory disease, and major criteria for the diagnosis of AIH include the elevation of antinuclear antibody (ANA) and/or anti-smooth muscle antibody (ASMA) for type 1 AIH and the elevation of anti-liver-kidney microsomal type 1 antibody (ALKM-1) or anti-liver cytosol type 1 antibody (ALC-1) for type 2 AIH [109].