With an estimated prevalence of one case per 20 million inhabitants (www.progeriaresearch.org; accessed on 7 July 2024), HGPS (#MIM176670) is considered to be one of the most severe laminopathies, originating from the aberrant splicing of the LMNA gene and the consequent expression of an abnormal lamin A protein, called progerin [118,119]. This evidence concerns the gene LMNA and laminopathy.