Thus, adipose tissue is affected specifically in the primary lipodystrophic laminopathies Dunnigan disease, HGPS, LMNA-atypical progeroid syndrome (APS) and MADA, and in the secondary lipodystrophic laminopathies MADB and NGPS [11]. The gene discussed is BANF1; the disease is autoimmune polyendocrinopathy.