In addition, variants in genes affecting lamin A/C processing and nuclear lamina structure, such as ZMPSTE24 (linked to mandibuloacral dysplasia type B [MADB]) and BANF1 (associated with Nestor-Guillermo progeria syndrome [NGPS]), can also result in accelerated ageing syndromes that share adipose tissue impairment [9]. The gene discussed is ZMPSTE24; the disease is mandibuloacral dysplasia with type B lipodystrophy.