In this sense, epigenetic studies on whole adipose tissue and preadipocytes, including the already-known miR335 but also HOTAIR involvement and other epigenetic marks, could improve understanding of the big phenotypic differences (when comparing FPLD vs. progeroid syndromes), or mild phenotypic differences in FPLD2 pending the specific LMNA variants. Here, LMNA is linked to progeroid syndrome.