On the other hand, the missense LMNA variant p.(Thr528Met) was identified in heterozygosity in subjects with FPLD2, in a compound heterozygous state in subjects with APS and severe partial lipodystrophy and, recently, in homozygosity in subjects with homogeneous APS clinical features with major musculoskeletal involvement [146]. Here, LMNA is linked to autoimmune polyendocrinopathy.