Atrogenes, such as atrophy-related muscle-specific E3 ligases, including muscle-specific RING finger protein 1 (MuRF1, also called tripartite motif containing 63 or TRIM63) and Atrogen1 (also called muscle-atrophy F-box protein or FBXO32), augment protein degradation, and increases in their expression levels serve as markers of atrophy [36]. This evidence concerns the gene PLXNA3 and Atrophy.