Our investigation can be supported by some interconnected disorders between the ATE–FA ratio and other parameters that affect vascular endothelial dysfunction: (i) cardiometabolic syndrome, particularly lipid disorders that are linked to insulin resistance and visceral adipose tissue (VAT) accumulation; (ii) oxidative stress damage (ATE related to SOD, GPx, CAT, and GSH) and a chronic inflammatory state (Hs-CRP and ferritin); (iii) saturated/unsaturated fatty acid ratio imbalance and athero-thromboembolic risk (Hcy, Ox-LDL, ET−1, and Lp (a)). This evidence concerns the gene SOD1 and Insulin resistance.