The GSH, SIRT1, Nrf2, and HO-1 levels declined in the ADHD model group versus the control group; however, the ADHD/HSP-25 and ADHD/HSP-50 groups showed enhanced SIRT1, Nrf2, and HO-1 levels versus the ADHD model group. This evidence concerns the gene HSPB1 and attention deficit-hyperactivity disorder.