Since we observed an inhibition of attachment, spreading and migration of transdifferentiated RPE cells by hr-galectin-1 in a previous work [42], and we now demonstrated that galectin-1 attenuates PDGF-BB-mediated proliferation of RPE cells via attenuation of PDGF-BB-induced AKT signaling, it is tempting to speculate that in vitreo-retinal diseases involving transdifferentiated RPE cells, galectin-1 may function to block an exaggerated wound-healing response, as observed in severe PVR. This evidence concerns the gene LGALS1 and Abnormal retinal morphology.