For PCa, we examine the influence of androgens, 3,5,3′-triiodo-L-thyronine (T3) stimulation of the thyroid hormone receptor (TR) β, the use of synthetic retinoids to selectively antagonize the retinoic acid receptor (RAR) γ, and activation of the vitamin D receptor (VDR) by 1α,25-dihydroxyvitamin D3 (1,25D3), the active metabolite of vitamin D3. The gene discussed is VDR; the disease is posterior cortical atrophy.