In mice with NAFLD, MEG3 overexpression showed a negative correlation with various lipogenesis-related genes, such as SREBP-1, carbohydrate response element-binding protein (ChREBP), LXRα, acetyl-CoA carboxylase 1 (ACC1), stearyl-coenzyme A desaturase 1 (SCD1), and fatty acid synthase (FAS) [83]. This evidence concerns the gene MEG3 and metabolic dysfunction-associated steatotic liver disease.