Yang et al. offer some additional explanation of the mechanism through which furin may act to promote CAD progression by reporting that higher expression in isogenic cell lines with the rs17514846 A/A genotype compared to C/C could be related to methylation of the C allele, which allows binding of transcription factor methyl-CpG binding protein 2 (MeCP2; responsible for repressing other protein-coding genes), thereby regulating FURIN expression [69]. Here, FURIN is linked to coronary artery disorder.