EIF2AK3 and Charcot-Marie-Tooth disease type 1B: D’Antonio et al. [19] showed that the PERK-CHOP arm is pathogenic in the CMT1B mouse model, and the pharmacological or genetic limitation of GADD34 could augment phosphorylated eIF2α, reduce misfolded protein accumulation in ER, and thus improve myelination [19].