In mediation analysis to investigate the potential mediating roles of the IDPs in the causal effect of the pleiotropic proteins on the NDs, we found that the effect of EGFR on AD can be mediated by 3 DTI parameters, including PLIC.RD, SCC.RD, and SCC.FA and the effect of TMEM106B on AD can be mediated by PLIC.RD. The gene discussed is TMEM106B; the disease is Alzheimer disease.