Among the several missense mutations reported so far, we have observed a significantly higher proportion of GBA1 mutation carriers in PD patients compared to healthy controls, primarily due to the presence of a population-specific mutation, such as the p.K198E variant, a single base substitution of a lysine to a glutamic acid at codon 198 (c.709A>G, g.4385A>G, exon 6, p.Lys198Glu) in a Colombian cohort [36]. This evidence concerns the gene GBA1 and Parkinson disease.