This is the first study in a sample of Colombian women that applies the MDR method to identify SNP-SNP interactions in 27 variants located in the genes THADA, LHCGR, FSHR, DENND1A, YAP1, HMGA2, ERBB3, AMHR2, TOX3, INSR, and AMH, associated with PCOS. The gene discussed is DENND1A; the disease is polycystic ovary syndrome.