In previous published [13,14] and unpublished pilot studies for the same cohort, we identified a negative association between rs7371084-LHCGR and rs4784165-TOX3, and a positive association between the SNPs rs10986105, rs10818854, rs7857605, and rs12337273 in the DENND1A gene and the risk of PCOS. This evidence concerns the gene LHCGR and polycystic ovary syndrome.