Therefore, this research aimed to evaluate the epistatic effect of 27 SNPs from the genes THADA, LHCGR, FSHR, DENND1A, YAP1, HMGA2, ERBB3, AMHR2, TOX3, INSR, and AMH in a sample of Colombian women with PCOS. The gene discussed is YAP1; the disease is polycystic ovary syndrome.