In addition, vascular biogenesis inhibitor 4 (VBIT-4), an inhibitor of VDAC1 oligomerization, effectively prevents the cytoplasmic accumulation of mtDNA and inflammation in motor neurons derived from induced pluripotent stem cells (iPSCs) obtained from patients with amyotrophic lateral sclerosis (ALS) patients. The gene discussed is VDAC1; the disease is amyotrophic lateral sclerosis.