In 2022, Zhang et al. published a comprehensive review that explored the physiological functions of furin in the brain, emphasizing how the dysregulated expression of furin and its substrates is linked to neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, cerebral ischemia, schizophrenia, and depression. The gene discussed is FURIN; the disease is major depressive disorder.