Literature searches were performed using the following keywords: non-alcoholic fatty liver disease, NAFLD, metabolic-associated steatotic liver disease, MASLD, non-alcoholic steatohepatitis, metabolic-associated steatohepatitis, MASH, liver disease, receptor activator of NF-κB, RANK, receptor activator of NF-κB ligand, RANKL, osteoprotegerin, OPG, hepatocellular carcinoma, HCC, insulin resistance, and denosumab. The gene discussed is TNFRSF11A; the disease is metabolic dysfunction-associated steatohepatitis.