There were no correlations of the tested parameters with age and gender in either AD, or PV or C. No correlation was observed between the tested parameters (IVL, hBD-2, IVL mRNA, hBD-2 mRNA, TPP2 mRNA and PSMB8 mRNA) and a single lesion duration in AD or in PV, but only in PV patients did disease duration correlate positively with hBD-2 mRNA: Spearman’s R = 0.53, p = 0.01 (Table 1). The gene discussed is PSMB8; the disease is Alzheimer disease.