AKT1 and primary cutaneous T-cell non-Hodgkin lymphoma: CD147 and CypA are both overexpressed in CTCL cells, blocking these proteins with an anti-CD147 antibody and/or anti-CypA antibody, suppressing the proliferation of CTCL cell lines, both in vitro and in vivo, via the downregulation of phosphorylated extracellular-regulated kinase 1/2 and Akt [98].