CD98 could also play a role in MDS, since it is known that the bone marrow microenvironment is altered in these pathologies and microenvironmental support is particularly important for the survival of MDS cells, so it is likely that leukemia–niche interactions that are important for the growth of AML play a role in the progression of MDS. The gene discussed is SLC3A2; the disease is myelodysplastic syndrome.