Another study demonstrates that CD147 knockdown in AML cells suppressed growth and proliferation, reduced protein levels of NF-κB (p65) and Bcl-2, Bcl-xL, and lowered the anti- and pro-apoptotic protein ratios of Bcl-2/Bax and Bcl-xL/Bax, clarifying the role of CD147 in the signaling pathways involved in the development of leukemia [43]. The gene discussed is BCL2; the disease is leukemia.