Importantly, the association of the altered glycosylation of CD147 and multidrug resistance in human leukemia [31], the profound influence of the ratio of the two glycosylated forms, HG-CD147 and LG-CD147, of CD147 on neoplastic diseases, and the correlation of the HG-CD147 form found in acute lymphoblastic leukemia (ALL) and its recurrence [32] have been demonstrated. This evidence concerns the gene BSG and leukemia.