Interestingly, Bougatef et al. observed that HUVEC endothelial cells express endogenous CD147, and showed that CD147 expression is responsible, through the transcription factor HIF-2α, for the increased production of soluble VEGF isoforms and its main receptor VEGFR-2, both in vitro and in experimental tumor models in vivo [123]. Here, EPAS1 is linked to neoplasm.