Our observation that the master regulator of cholesterol synthesis, SREBP2, does not appear to be a major factor in the regulation of tumour growth and metastasis is consistent with another study demonstrating that RORγ, a member of the RAR-related orphan receptor family, can also act as the major driver of cholesterol biosynthesis in triple-negative breast cancer [31]. Here, SREBF2 is linked to triple-negative breast carcinoma.