TP53BP2 and neoplasm: Our results are more in line with the findings of Tang et al. [50] who reported that the enhancement of cholesterol synthesis in 4T1 and MDA-MB-231 tumour cells through knockdown of the negative regulator of SREBP2, ASPP2, led to elevated cholesterol levels, increased migration and invasion, and more lung metastases in a lung colonisation assay.