BMP4 and breast cancer: Given the profound inhibition of individual cholesterol homeostasis genes by BMP4 (Figure 3c) and the increasingly recognised pro-tumourigenic roles of this pathway in breast cancer progression [31,32,33], we explored further the interactions between BMP4 signalling and cholesterol biosynthesis and the feasibility of therapeutically targeting this pathway to reproduce the anti-metastatic impact of BMP4.