Given its crucial role in cholesterol metabolism, ACAT1 has emerged as a therapeutic target for treating a broad spectrum of diseases, including atherosclerosis, cancer, dyslipidemia, and neurodegenerative diseases like Alzheimer’s disease (AD) and Niemann-Pick Type C disease (NPCD) [19,20,21,22,23,24,25,26,27,28,29,30,31]. Here, ACAT1 is linked to neurodegenerative disease.