Analysis of mRNA expression in 52 normal and 495 tumor tissues from the Prostate Adenocarcinoma database identified mutations in ATG9B, DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1), HSPB8, NKX2-3, and TP63 genes significantly associated with an increased risk of developing prostate cancer. The gene discussed is DNAJB1; the disease is Familial prostate cancer.