Acts as an OXPHOS inhibitor (inhibiting complexes I, II, IV) in colon cancer 3-D microtissues;Acts as an iron chelator;Induces autophagy-dependent cell death and mitophagy through BNIP3/BNIP3L activation in glioblastoma cells (U251, MZ54, NCH644) and organotypic brain slice cultures. The gene discussed is BNIP3L; the disease is glioblastoma.