The accumulation of p62 supports tumor development and cancer cell growth via the activation of Nrf2, mTORC1, TRAF6 (tumor-necrosis-factor-receptor-associated factor 6), TNFa (tumor necrosis factor α), and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) [54]. The gene discussed is SQSTM1; the disease is cancer.