Analysis of mRNA expression in 52 normal and 495 tumor tissues from the Prostate Adenocarcinoma database identified mutations in ATG9B, DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1), HSPB8, NKX2-3, and TP63 genes significantly associated with an increased risk of developing prostate cancer. This evidence concerns the gene DNAJB1 and prostate adenocarcinoma.