For example, epigallocatechin gallate (EGCG) can effectively inhibit the pathway involving AP-2α and vascular endothelial growth factor (VEGF), leading to the downregulation of downstream molecules such as MDR-1 and P-gp, ultimately resulting in the inhibition of proliferation and reversal of 5-fluorouracil (5-FU) resistance in GC cells [13]. This evidence concerns the gene VEGFA and gastric cancer.