Myh3 is also one of the most highly downregulated genes, which plays a pivotal role in fetal muscle development; defects in the human ortholog are associated with Freeman–Sheldon syndrome, distal arthrogryposis 8 (DA8), and autosomal dominant spondylocarpotarsal synostosis, which can present skeletal abnormalities, such as kyphoscoliosis and bony fusions [45]. This evidence concerns the gene MYH3 and Freeman-Sheldon syndrome.