CD4 and myeloid sarcoma: In another study by using qRT-PCR analysis, Hosseini et al. showed that the levels of CD4+ T-cell-derived miR-223 significantly enhanced during the relapsing phase of MS compared to the remitting phase and healthy individuals; therefore, miR-223 was accompanied by increased Th17 cells and decreased Treg cells, a potential role in positively regulating the pathogenic cascade that leads to EAE [28].