As an inverse relationship between Par-4 and PPARγ was noted across mouse embryonic cells, pre-adipocytes, and adult fibroblasts, regulation of PPARγ by Par-4 can be further explored using advanced human adipose tissue culture methods [37], as well as obesity and diabetes models [38,39], to restore insulin sensitivity. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.