Moreover, in view of the tumor suppressor function of Par-4 [40,41,42,43,44,45,46,47,48,49,50,51,52], its inverse relationship with PPARγ, and abnormal lipid metabolism caused by increased PPARγ expression in cancer [53,54,55,56,57], it will be important to determine the functional significance of the inverse relationship between Par-4 and PPARγ in cancer. The gene discussed is PPARG; the disease is cancer.