The study of exercise capacity in patients with chronic obstructive pulmonary disease, systemic sclerosis, and bronchiectasis showed an inverse relationship between e-selectin values and the forced expiratory volume in 1 s, forced vital capacity, and lung diffusing capacity [32,33,34], which additionally suggests its importance in the pathogenesis of vascular changes and their clinical consequences in states of hypoxia. Here, SELE is linked to systemic sclerosis.