The evaluation of molecular markers (Nrf2, Slc7a11, P53, and p-Jnk) indicated the absence of involvement of ferroptosis in the testes of rats with induced varicocele [38], but it has been reported that bilateral varicocele leads to ferroptosis of human spermatozoa and affects semen quality in infertile men [5]. The gene discussed is SLC7A11; the disease is varicocele.