Glaucoma LC cells were also transfected with siRNA targeting β3 integrin and the results, at day 3 post-transfection, showed a clear significant inhibition of ECM gene transcription for Col1A1 (from 1.022 ± 0.073 to 0.168 ± 0.035), αSMA (from 0.948 ± 0.068 to 0.097 ± 0.022), fibronectin (from 0.892 ± 0.067 to 0.134 ± 0.0328), and vitronectin (from 0.877 ± 0.065 to 0.075 ± 0.021) (p < 0.05, n = 5) (Figure 5). This evidence concerns the gene ACTA1 and glaucoma.