EDN1 and cardiac hypertrophy: Studies in several models, such as cardiac hypertrophy and ischemia/reperfusion injury, have shown that SIRT1 has a cardioprotective effects through PGC-1α-dependent mechanisms by decreasing oxidative stress, ET-1 production, and pro-inflammation factors; inhibiting apoptosis; modulating eNOs activity; and promoting autophagia [44,45].