Given that NuF effectively inhibits the expression of PTHrP and ameliorates fat wasting (Figure 2B) and that PTHrP is a mediator of AT browning and tumor-induced cachexia, the protein and mRNA levels of lipolytic enzymes and thermogenic effectors involved in the browning process needed to be known in the first place (Figure 4A,B). This evidence concerns the gene PTHLH and neoplasm.