In humans, upregulated K8/18 expression promotes tumor progression and is predictive of a poor prognosis in multiple cancers: increased KRT8 expression induces cell apoptosis and promotes cell proliferation, cell migration, invasion, and EMT [104,105,106], while increased KRT18 expression is associated with the increased viability, migration, and invasion of cancer cells and the selective regulation of cell proliferation and apoptotic genes [107,108,109]. The gene discussed is KRT8; the disease is cancer.