To circumvent hypercalcemia associated with systemic high 1,25(OH)2D concentrations, we previously showed that inflammation- and gut-homing macrophages (MAC cells) engineered to overexpress the 1α-hydroxylase (MAC-CYP cells) robustly suppressed experimental colitis without the hypercalcemia [7,11]. Here, PPIG is linked to hypercalcemia disease.