A recent study led by Dr. Yang’s group demonstrated two dominant roles for SOX9 in YAP1 alone-driven liver cancer: indispensable roles in lineage determinants for HC-to-iCCA formation and responsibility for the severity of YAP1-HCC using AAV8-Cre;Sox9(f/f)-mediated Sox9 ablation [14]. The gene discussed is SOX9; the disease is hepatocellular carcinoma.