However, Dnmt1 re-expression in Sox9 CKO livers slightly but significantly restored tumor formation driven by Akt-NRAS (Figure 6H), but not Akt-YAP1 (Figure 6J), implying the partial involvement of Dnmt1 in Akt-NRAS tumor development under the SOX9. The gene discussed is YAP1; the disease is neoplasm.