Among the various factors implicated in melanoma genesis, the roles of lysyl oxidase-like 3 (LOXL3), Snai1 family transcriptional repressor 1 (SNAI1), and nestin (NES) have garnered significant attention due to their involvement in key pathways that regulate tumor growth, metastasis, and cellular differentiation [16,17]. This evidence concerns the gene LOXL3 and neoplasm.