EPHX2 and non-proliferative diabetic retinopathy: We previously reported that an increase in the expression of the sEH in the retina and the increased generation of the DHA diol, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), were responsible for the dissolution of pericyte endothelial cell junctions and the development of non-proliferative diabetic retinopathy [19].