Growing evidence has indicated that dysregulation in DNA sensing, particularly from the cGAS-STING axis, plays an important role in driving inflammatory responses in a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), Huntington’s disease (HT), TBI, and FTD, and more recently, AD [237,238,239,240,241,242,243,244,245]. This evidence concerns the gene CGAS and amyotrophic lateral sclerosis.