Small-molecule inhibitors targeting the NLRP3 inflammasome, such as MCC950 (also known as CRID3) [176,177], CY-09 [178], and OLT1177 (dapansutrile) [179], have shown efficacy in preclinical models of AD by attenuating inflammasome activation, reducing neuroinflammation, and ameliorating cognitive deficits [165,171]. Here, NLRP3 is linked to Alzheimer disease.