In HCFBs and MCFBs, PIEZO1 activated by Yoda1 mediates Ca2+ inward flow and intracellular Ca2+ is involved in the p38MAPK/IL-6 pathway of myocardial hypertrophy and fibrosis, but this pathway may be influenced by the matrix or tissue stiffness surrounding PIEZO1 [83,84] (Figure 5). Here, PIEZO1 is linked to cardiac hypertrophy.