PIEZO1 and peripheral arterial disease: However, a recent research study found that in mouse hindlimb ischemia (HLI) model-induced peripheral artery disease (PAD), the activation of PIEZO1 in Møs by the enhanced stiffness of the surrounding microenvironment activated downstream CaMKII (calcium/calmodulin-dependent protein kinase II)/ETS1 (ETS proto-oncogene 1) signaling, and the transcriptional inactivation of FGF2 inhibited vascular regeneration and reperfusion, ultimately leading to ischemic injury of the hindlimb [59].