Mechanistically, in atrial-derived HL-1 cells from hypertensive rats, Ca2+ inward flow induced by PIEZO1 activated by high mechanical stress decreased L-type calcium currents through the CaM/Src/Pitx2 (paired like homeodomain 2) pathway, which shortened APD and increased AF susceptibility [89]. The gene discussed is PIEZO1; the disease is atrial fibrillation.