PIEZO1 and triple-A syndrome: It was found that during the development of AAA, transmural Møs of the abdominal aorta release Netrin-1 to act on VSMCs, followed by the upregulation of the cytoskeletal cross-linker α-Actinin2 in the VSMCs and progression to a mechanically stiff state, which in turn activates PIEZO1 and downstream calcium signaling in VSMCs.