Mcm3 is overexpressed in most tumors in human studies [24], and MCM6 expression is positively correlated with cell proliferation, migration, invasion, and immune response in numerous cancer types, including breast cancer [25], hepatocellular carcinoma [26], lung cancer [27], and esophageal squamous cell carcinoma [28]. The gene discussed is MCM6; the disease is esophageal squamous cell carcinoma.