The cellular abnormalities observed in mice lacking GDE2 (Gde2KOs) reflect the neuropathologies observed in AD, ALS, and ALS/frontal temporal dementia (FTD), and Gde2KO mice show motor and cognitive changes observed in mouse models of AD, ALS, and ALS/FTD [31,32]. This evidence concerns the gene GDPD5 and Alzheimer disease.