Moreover, the expression of only a few of the entire profile of chemokines expressed in GBM tumors was preserved in spherical cultures (mainly CCL2, CX3CL1, CXCL16, CXCL11, CXCL10, CXCL12, CXCL26, CXCL2, and CXCL14, Figure 3b). This evidence concerns the gene CXCL2 and glioblastoma.