The decrease in CXCL14 expression in primary cultures may have been due to several factors, e.g., hyperoxic culture conditions compared to tumor tissues (as CXCL14 is reported to be overexpressed in hypoxia [51]), the fact that its expression is regulated by GBM TME cells [50], and the fact that in tumors, it is additionally highly expressed by cancer-associated fibroblasts [50], a cell type not included in our analysis. This evidence concerns the gene CXCL14 and cancer.