According to an extensive survey of 1540 patients with AML published in 2014, among 5234 driver mutations across 76 genes or genomic regions, it was found that most patients had more than two driver mutations and frequent mutations were NPM1, DNMT3A, FLT3ITD, NRAS, TET2, and PTPN11 in this order [43]. Here, NPM1 is linked to acute myeloid leukemia.