RUNX1T1 and acute myeloid leukemia: For an unknown reason, this event seems to fit the intrinsic properties of stem cells or very immature myeloid cells close to stem cells and the resultant mutant clone would stay in niche for a long period of time, which is supported by a report that AML1-ETO (RUNX1-RUNX1T1) transcripts could be detected in Guthrie cards from newborns who develop AML later in life [37].