Furthermore, chronological analysis of the clonal composition of AML samples has revealed that RUNX1-RUNX1T1 is present early in the preleukemic clone, is also found in clones when patients relapse, and leads to nonleukemic hematopoiesis in the marrows of mice in xenotransplantation models [38]. Here, RUNX1T1 is linked to acute myeloid leukemia.