Accordingly, many groups, our own included (e.g., [16,17,18,19,20]), devoted considerable efforts to characterize signaling pathways that are altered in cancer, to identify the many (hundreds and thousands) of factors that play roles in each pathway (e.g., in the p53 “fireworks” [21,22]), and to conceptualize how these various pathways interact to influence cell fate. The gene discussed is TP53; the disease is cancer.