Strikingly, IM used at 0.02 μM was still sufficient enough to effectively inhibit KIT signaling in GIST T-1 cells (Figure 2), which was accomplished with the increased production of VEGF-A, thereby illustrating functional connection between the KIT inhibition and activation of VEGFR signaling in IM-naive GIST T-1 cells. This evidence concerns the gene KIT and gastrointestinal stromal tumor.