KDR and gastrointestinal stromal tumor: To examine an outcome of the crosstalk between FGF/FGFR and VEGF/VEGFR signaling pathways in IM-resistant GISTs (i.e., GIST-T1R and GIST 430 cells), we treated them by the inhibitors of VEGFR signaling (i.e., sunitinib or regorafenib) alone or in combination with BGJ 398.