KDR and gastrointestinal stromal tumor: Given that GIST T-1R cells exhibited the signs of autocrine activation of FGF/FGFR and VEGF/VEGFR pathways and taking into account previous reports illustrating the ability of FGF2 to activate the VEGF/VEGFR pathway [26,27], we thought to examine this possibility for IM-resistant GISTs.