The close proximity of the aforementioned RTKs or their physical interaction might be responsible for the decreased activation of VEGFR signaling in FGFR-inhibited cells and explain the impressive synergy score rates observed between FGFR and VEGFR inhibitors in IM-resistant GIST T1-R cells (Figure 7, Table 2). Here, KDR is linked to gastrointestinal stromal tumor.