Besides of the effective controlling of tumors angiogenesis, both of VEGF-VEGFR and FGF-FGFR signaling pathways are currently known as potent regulators of tumor immunity via the modulation of the tumor microenvironment (TME) by inducing macrophage polarization [52] and enhancing the infiltration and activity of cytotoxic T lymphocytes, mature dendritic cells, and NK cells [53,54,55]. This evidence concerns the gene KDR and neoplasm.