The opposing effects of IM on VEGF production by GIST cells in vitro might be due to IM used in 1 μM of for these studies [44,45], therefore the down-regulation of VEGF production in IM-treated GIST were due to the decreased viability, which was evidenced by the MTT-based assay [45]. This evidence concerns the gene VEGFA and gastrointestinal stromal tumor.