For example, an increase in Survivin in cancer cells leads to the upregulation of various signaling pathways, including phosphatidylinositol 3-kinase (PI3K/AKT), Wnt/β-catenin, EMT, VEGF, and other regulators of metastasis and angiogenesis [1,2,53,54,55]. This evidence concerns the gene BIRC5 and cancer.