The purpose of this review is to describe the various entities typically demonstrating CD8-positivity, namely CD8+ MF, CD8+ LyP, SPTCL, PCGDTL, CD8+ AECTCL, and acral CD8+ T-cell lymphomas, with respect to clinical features prognoses and treatment regimens (Figure 1). Here, CD8A is linked to T-cell non-Hodgkin lymphoma.